Orbitz via goSeek offers 2-Night Stays at the Wynn Las Vegas on the Strip in Las Vegas, NV, with prices starting from $374.24 via coupon code "HOLIDAY". (We found this rate on Christmas Eve, December 24.) At $187 per night, that's the lowest price we could find for a 2-night stay by $66. This 5-star hotel has an Expedia rating of 94% based on 5,512 reviews and TripAdvisor ranks it #5 out of 267 hotels in Las Vegas.
Of note: An additional daily resort fee of $39.20 applies.